Publications

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Journal Articles

Hydrogen Evolution and Dynamics in Hydrogel Electrochemical Cells for Ischemia-Reperfusion Therapy

Published in Nature Chemical Engineering, 2025

A hydrogel electrochemical cell integrating electrolyte, reaction medium, and therapeutic delivery reservoir for electronically controlled, localized hydrogen delivery, validated in preclinical models.

Recommended citation: Wen Li, Jing Zhang, et al., B Tian. (2025). "Hydrogen Evolution and Dynamics in Hydrogel Electrochemical Cells for Ischemia-Reperfusion Therapy." Nature Chemical Engineering.
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Gold-modified nanoporous silicon for photoelectrochemical regulation of intracellular condensates

Published in Nature Nanotechnology, 2025

We reveal the mechanism by which a nanoporous silicon photocatalyst generates H₂O₂ under physiological conditions, and demonstrate precise modulation of intracellular stress granule formation to enhance cellular resilience — with efficacy validated in an ex vivo myocardial ischemia-reperfusion model.

Recommended citation: Jing Zhang, Pengju Li, Jiping Yue, Lingyuan Meng, Wen Li, et al., Bozhi Tian. (2025). "Gold-modified nanoporous silicon for photoelectrochemical regulation of intracellular condensates." Nature Nanotechnology.
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Monolithic silicon for high spatiotemporal translational photostimulation

Published in Nature, 2024

We demonstrate leadless, multisite optical pacing of cardiac systems — including the first in-vivo optical pacing of a pig heart — using a non-genetic, semiconductor-based platform adaptable for minimally invasive clinical procedures.

Recommended citation: Pengju Li, Jing Zhang, Hidenori Hayashi, Jiping Yue, Wen Li, et al., Bozhi Tian. (2024). "Monolithic silicon for high spatiotemporal translational photostimulation." Nature.
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Perspectives on Multiscale Colloid-Based Materials for Biomedical Applications

Published in Langmuir, 2023

A perspective on synthetic colloid-based materials at the nano-, micro-, and macroscales and their emerging potential in biomedical applications including spatial imaging, localized drug delivery, and biointerfaces.

Recommended citation: Wen Li, Judah Huberman-Shlaes, B Tian. (2023). "Perspectives on Multiscale Colloid-Based Materials for Biomedical Applications." Langmuir.
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A Strong and Rigid Coordination Adaptable Network that Can Be Reprocessed and Recycled at Mild Conditions

Published in CCS Chemistry, 2022

We designed a coordination adaptable network (CoAN) with high mechanical rigidity that can be rapidly reprocessed and recycled at mild temperatures with no loss in mechanical performance — superior to previously reported covalent adaptable networks.

Recommended citation: Wen Li, Hong-Qin Wang, Wen-Tong Gao, et al., Cheng-Hui Li. (2022). "A Strong and Rigid Coordination Adaptable Network that Can Be Reprocessed and Recycled at Mild Conditions." CCS Chemistry.
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